RE:NEW. Biologically active food supplement useful to promote the body’s natural defenses and in all cases of greater need for useful components to improve the immune system. RE:NEW stimulates the immune system to improve gastrointestinal health by limiting damage from infection or injury. Based on the millennia-old medicinal and dietary mushrooms of the Chinese tradition and other cultures. They represent the most interesting natural sources of bioactive compounds capable of stimulating the innate immune system. Mushrooms also act as prebiotics to stimulate the growth of the intestinal microbiota, ensuring intestinal health and function.
RE:NEW. Innovative formulation based on medicinal mushroom extracts and powders, contains the main mushrooms reported to have immunomodulatory and immunostimulant activity: 6:1 aqueous extract of Ganoderma lucidum, Maitake powder (Grifola frondosa), Shiitake powder (Lentinula edodes), Cordyceps powder (Cordyceps sinensis), Mushroom extract (Agaricus blazei)Pleurotus mycelium powder (Pleurotus ostreatus), Chaga powder (Inonotus obliquus), 5:1 aqueous extract of Poria cocos and Lion’s Mane powder (Hericium erinaceus).
Medicinal mushrooms are used in autoimmune diseases because of their properties as adaptogens of the body and immunostimulants of the immune system. Autoimmune diseases are pathologies determined by the alteration of the immune system that originates abnormal immune responses directed against components of our organism. Common denominator of autoimmune diseases is a chronic inflammatory state of the affected tissue, which varies depending on the disease. The mushrooms used in are among the most interesting natural sources of compounds able to stimulate the immune system and represent fundamental components of traditional medicines all over the world1. The mushrooms contained in RE:NEW are reported to have prebiotic effect through the modulation of intestinal microbiota.
Recently the interest of the scientific community for mushrooms as a potential source of bioactive compounds has increased and in the last few years many researches have been published reporting their immunostimulating action. The main components are lectins, polysaccharides, polysaccharide protein complexes, polysaccharide peptides, triterpenes, phenolic compounds and flavonoids and the reported actions are antiviral, antibacterial, antifungal, antioxidant, anti-inflammatory, antitumor, imunomodulatory2.
The use of mushrooms in ancient traditional therapies dates back to at least the Neolithic period. For millennia, mushrooms have been used by humans as a source of essential nutrients and substances of medicinal interest. Some of them exhibit stimulating activities of the innate and adaptive immune systems. They proliferate and activate components of the innate immune system such as natural killer (NK) cells, neutrophils and macrophages and stimulate the expression and secretion of cytokines. These cytokines in turn activate adaptive immunity through promotion of B cells to produce antibodies and stimulation of T cell differentiation into T helper (Th) 1 and Th2 cells, which mediate cellular and humoral immunity, respectively3. Their beneficial substances act primarily by enhancing the host immune system. This process includes the activation of dendritic cells, NK cells, T cells, macrophages and cytokine production. Several products, mainly polysaccharides (particularly β-glucans), have been tested in clinical trials and are marketed for their activity. In addition, mushroom polysaccharides may help to prevent oncogenesis, as they have shown direct antitumor activity against various cancers in some studies and could prevent cancer metastasis4.
- Wasser, S. (2014). Medicinal mushroom science: Current perspectives, advances, evidences, and challenges.Biomedical journal, 37(6).
- Öztürk, M., Tel-Çayan, G., Muhammad, A., Terzioğlu, P., & Duru, M. E. (2015). Mushrooms: a source of exciting bioactive compounds. InStudies in Natural Products Chemistry (Vol. 45, pp. 363-456).
- Borchers, A.T. et al. (2008) The immunobiology of mushrooms. Exp. Biol. Med. 233, 259–276
- Zhang, M., Cui, S. W., Cheung, P. C. K., & Wang, Q. (2007). Antitumor polysaccharides from mushrooms: a review on their isolation process, structural characteristics and antitumor activity.Trends in Food Science & Technology, 18(1), 4-19.