Blue Kollagen It is an all-in one formula designed to promote collagen synthesis, With powerful anti-aging components it is especially designed to improve the health of skin, hair, nails, and reduce wrinkles with the rejuvenating effect.
Blue Kollagen. It is a nutraceutical composed of hydrolyzed marine collagen 10 g (10% hydroxyproline), low molecular weight plant-derived hyaluronic acid, cysteine 250 mg, red algae extract Lithotamnium calcareum (7% silica), vitamin C, resveratrol, astaxanthin, biotin , zinc, lycopene. Useful in all cases of reduced dietary intake or increased need for components useful for improving collagen synthesis in the body and with anti-aging and restructuring properties.
COLLAGEN SYNTHESIS COMPLEX. (Marine Collagen and Hyaluronic Acid, Vitamin C, Silicon and Resveratrol)
Collagen is one of the most important proteins in vertebrates and accounts for one-third of the total proteins in the human body, where it plays a key role in the structure and function of organs and tissues, such as skin, cartilage, and muscle tissue. Over time, collagen fibers become damaged: by age 25, cells begin to lose the ability to synthesize collagen, the production of which decreases by an average of 1.5 percent per year. This process is accentuated beyond age 45 with a decrease of more than 35% at age 60 and loss of thickness and strength.
In addition to time some other factors accelerate collagen loss: intense physical activity, trauma, menopause, overweight, hormonal therapies, incorrect dietary style, cancer treatments, intense and continuous exposure to sunlight, particular environmental conditions (pollutants, smoking, stress). Supplementation with collagen has also shown benefits for preventing neurodegenerative mechanisms, cardiovascular health, and intestinal function; in functional aesthetics it is an aid for weight control and maintaining healthy gums, hair, and nails. In sports, it promotes recovery and protects joints.
Marine Collagen & Hyaluronic Acid. Thanks to the synergy of marine collagen and hyaluronic acid, Blue Kollagen is particularly useful in aiding the process of recovery and regeneration of skin cells and connective tissue in the face and throughout the body. It visibly reduces the appearance of aged skin that is deeply nourished and restores its vitality. Skin radiance increases, as does nail health. The product makes the skin plumper and regains its youthful appearance.
Marine collagen is a pure form of hypoallergenic protein produced by fish. The remaining fish skin from food production is thoroughly washed, then hydrolyzed enzymatically to produce marine collagen peptides, which have a low molecular weight and easy digestion and absorption. Marine collagen differs from collagen of bovine or porcine origin in that it contains higher amounts of the amino acids glycine and proline, which have been particularly associated with promoting healthy hair, skin, and nails1-4.
It is a powerful cellular antioxidant. Helps maintain the integrity of mesenchymal-derived substances (connective tissue, bone tissue, and dentin). Essential for the formation of collagen, and for the formation of hydroxyproline from proline through the hydroxylation reaction biochemical process essential for the maintenance of connective tissue.
Vitamin C (ascorbic acid) is a cofactor of several enzymes, particularly proline hydroxylase, necessary for collagen synthesis. It cannot be produced by the body and must be obtained from the diet. It is essential for collagen formation and helps maintain the integrity of mesenchymal-derived substances (connective tissue, bone tissue, and dentin). In the absence of vitamin C, cells cannot hydroxylate proline to hydroxyproline resulting in collagen instability. In fact, proline hydroxylation is an essential biochemical process for the maintenance of connective tissue. Blue Kollagen contains natural vitamin C extracted from Malpighia glabra, a plant that grows in Central and South America. The fruit called acerola is rich in natural vitamin C that is best assimilated by the body. Acerola fruits promote the body’s natural defenses, have restorative and antioxidant5.
Lithothamnium calcareum. Silicon is a structural element of connective tissue and enters into the constitution of major macromolecules such as elastin, collagen, proteoglycans, and glycoproteins, promoting their regeneration. Silicon content is closely related to optimal skin conditions, such as hydration rate, elasticity, absence of wrinkles and expression lines, and skin and dermal regeneration capacity. It also acts as a metabolic protector by several mechanisms: it opposes lipid peroxidation responsible for the release of free radicals, counteracts the glycosylation of connective tissue proteins that causes stiffness and sclerosis, regulates and stimulates fibroblast mitosis, and because of this property, plays an essential role in the regeneration process of skin and epidermal cells, and finally is a cofactor of elastin synthesis. Silicon plays a key role in collagen synthesis by influencing the process of hydroxylation of proline into hydroxyproline. The silicon in Blue Kollagen is derived from Lithothamnium calcareum a red alga consisting of a robust thallus that is formed by calcareous deposits in the cell wall. These deposits consist of minerals in highly bioavailable organic form such as silicon, calcium, and magnesium.
Resveratrol. Collagen is degraded by metalloproteinases (MMPs), proteolytic enzymes that break the long protein chains that make up collagen, forming shorter fragments without mechanical properties. MMPs are a family of molecules similar in chemical structure, with different specificities for a wide variety of substrates, capable of degrading all components of the extracellular matrix (collagen, elastin, proteoglycans). The MMPs most involved in skin aging processes are MMP1, which initiates the degradation of type I and III collagen; MMP9, which operates further fragmentation into smaller peptides; while MMP2 attacks type IV collagen, contributing to wrinkle formation. In young skins not exposed to sunlight, collagen synthesis by fibroblasts and its degradation by MMPs are in constant balance, so as to ensure the physiological replacement of structural macromolecules, maintaining their content and functionality and preserving skin integrity. With increasing age there is a progressive change in this balance with gradual reduction in the synthesis of collagen precursor peptides, associated with increased degradation of mature collagen. The consequence of this degenerative phenomenon is a general disorganization of collagen fibers, which partially lose their supporting role, causing a partial atrophy of the extracellular matrix, which becomes lax and lacking in tone.
ANTI-AGING COMPONENTS to improve the condition of the skin. (Astaxanthin, Lycopene)
Blue Kollagen contains natutal carotenoids that accumulate in corneocytes and sebum, protecting the skin and performing photoprotective action.
Astaxanthin is a natural red-orange pigment belonging to the broad family of carotenoids and produced naturally by certain microorganisms, such as the microalgae Haematococcus pluvialis, Chlorella zofingiensis and Chlorococcum. It is a potent antioxidant, combating oxidative damage through several mechanisms: neutralization of singlet oxygen, elimination of free radicals, preservation of cell membranes, enhancement of immune system function.
Liposoluble, it accumulates in the skin after oral administration and defends it of aging. In several studies, oral supplementation of astaxanthin has been shown to reduce wrinkles9,10, improve skin parameters and conditions in women and men11, prevent the effects of UV-A radiation and collagen decrease by inhibiting metalloproteinases MMP-1 and elastase12-15.
Lycopene Lycopene is an antioxidant carotenoid actively studied for its photoprotective action carried out against UV-induced damage in human skin. Lycopene is abundantly present in tomatoes, and its consumption is associated with reduced risk of chronic cardiovascular disease, benign prostatic hypertrophy, and cancer (particularly of the prostate). One of the actively studied beneficial effects of lycopene is its photoprotective action against UV-induced damage to human skin17-19. The concentration of lycopene in the skin correlates with its level in plasma20 . The accumulation of this carotenoid in corneocytes and sebum during its supplementation is well documented21-23.
HAIR AND NAIL HEALTH. (Biotin, Zinc L-Cysteine)
Blue Kollagen Contains a selected combination of vitamins, minerals, and amino acids to stimulate hair growth, restore hair structure, strengthen nails, and maintain skin health, in synergy with other components.
Zinc aids cell regeneration. It is an essential trace element required by about 300 enzymes, contributing to growth, development, wound healing, immune function, and collagen synthesis24. Poor dietary intake of meat and fish can cause deficiencies. Alopecia is often related to zinc deficiency25 . Zinc strengthens hair by promoting keratin synthesis, has tissue-regenerating activities, is also useful in acne, assists antioxidant activity at the cellular level, and slows macular degeneration that physiologically affects our vision as we age.
Biotin is a coenzyme that belongs to the B-vitamin group (Vitamin B7 or Vitamin H). It is an element involved in the process of metabolism and fatty acid formation; in fact, once taken, it is first absorbed by the ileum and then transported to the liver and finally to other tissues. It can be found in foods such as: cauliflower, carrots, spinach, mushrooms, cheese, eggs, beans, fish, white meat and red meat. It is important for scalp health, but also for skin health. In fact, this substance regulates sebum production and is useful in cases of seborrheic dermatitis or oily hair. A recent study demonstrated a 25 percent increase in nail plate thickness in patients with brittle nails following biotin supplementation.26- 28
L-cysteine is a conditionally essential sulfur amino acid, a building block of protein. Cysteine is a key component of the protein keratin due to its ability to form disulfide bridges that impart strength and stiffness to the protein. Cysteine helps build the keratin structure of hair and nails. Keratin is a fibrous protein that makes up the structure of skin, nails, and hair. The cortex of hair contains keratin molecules grouped iin a fibrous structure that contains about 75% L-cysteine29. Deficiencies in L-cysteine alter keratin structures, causing weakened hair ranno and will be prone to breakage. Hair consists of three layers, the cuticle, cortex and pith. L-Cysteine is a sulfur compound precursor in keratinization, an important process in hair, skin and nail formation. L-Cysteine is a constituent of L-glutathione, a cofactor of glutathione peroxidase, an antioxidant enzyme that counteracts oxidative stress in the body.
Supplementation with Blue Kollagen30-37:
- Improve skin quality
- Reduce wrinkles
- Maintains skin elasticity and firmness
- Protects microcirculation
- Promotes collagen and elastin synthesis
- Inhibits collagen degradation
- Reduces blemishes
- De Luca C, Mikhal’chik EV, Suprun MV, Papacharalambous M, Truhanov AI, Korkina LG. Skin Antiageing and Systemic Redox Effects of Supplementation with Marine Collagen Peptides and Plant-Derived Antioxidants: A Single-Blind Case-Control Clinical Study. Oxid Med Cell Longev. 2016;2016:4389410. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails. Hexsel D, Zague V, Schunck M, Siega C, Camozzato FO, Oesser S. J Cosmet Dermatol. 2017 Aug 8. doi: 10.1111/jocd.12393.
- Schunck M, Zague V, Oesser S, Proksch E. Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology. J Med Food. 2015 Dec;18(12):1340-8.
- Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A, König D. Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. Br J Nutr. 2015 Oct 28;114(8):1237-45.
- Belwal, T., Devkota, H. P., Hassan, H. A., Ahluwalia, S., Ramadan, M. F., Mocan, A., & Atanasov, A. G. (2018). Phytopharmacology of Acerola (Malpighia spp.) and its potential as functional food.Trends in Food Science & Technology, 74, 99-106.
- Li, C., Wu, W., Jiao, G., Chen, Y., & Liu, H. (2018). Resveratrol attenuates inflammation and reduces matrix-metalloprotease expression by inducing autophagy via suppressing the Wnt/β-catenin signaling pathway in IL-1β-induced osteoarthritis chondrocytes.RSC advances, 8(36), 20202-20210.
- Baralic, M. Andjelkovic, B. Djordjevic, N. Dikic, N. Radivojevic, V. Suzin- Zivkovic, S. Radojevic-Skodric, S. Pejic, Effect of astaxanthin supplementation on salivary IgA, oxidative stress, and inflammation in young soccer players, Evid. Complement. Altern. Med. 2015 (2015) 1–9
- Hu, D. Nagarajan, Q. Zhang, J.-S. Chang, D.-J. Lee, Heterotrophic cultivation of microalgae for pigment production: a review, Biotechnol. Adv. (2017) 54–67.
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- M. Lyons, N.M. O’Brien, Modulatory effects of an algal extract containing astaxanthin on UVA-irradiated cells in culture, J. Dermatol. Sci. 30 (1) (2002) 73–84.
- Suganuma, H. Nakajima, M. Ohtsuki, G. Imokawa, Astaxanthin attenuates the UVA-induced up-regulation of matrix-metalloproteinase-1 and skin fibroblast elastase in human dermal fibroblasts, J. Dermatol. Sci. 58 (2) (2010) 136–142. K. Tominaga, N. Hongo, M. Karato, E. Yamashita, Cosmetic benefits of astaxanthin on humans subjects, Acta Biochim. Pol. 59 (1) (2012) 43.
- Hama, K. Takahashi, Y. Inai, K. Shiota, R. Sakamoto, A. Yamada, H. Tsuchiya, K. Kanamura, E. Yamashita, K. Kogure, Protective effects of topical application of a poorly soluble antioxidant astaxanthin liposomal formulation on ultra- violet‐induced skin damage, J. Pharm. Sci. 101 (8) (2012) 2909–2916.
- D. Santos, T.B. Cahú, G.O. Firmino, C.C. de Castro, L.B. Carvalho Jr, R.S. Bezerra, L.L. José Filho, Shrimp waste extract and astaxanthin: rat alveolar macrophage, oxidative stress and inflammation, J. Food Sci. 77 (7) (2012).
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